Motohiro Sekiya Selected Research

Fatty Acid Elongases

1/2020	Hepatocyte ELOVL Fatty Acid Elongase 6 Determines Ceramide Acyl-Chain Length and Hepatic Insulin Sensitivity in Mice.
9/2011	Macrophage Elovl6 deficiency ameliorates foam cell formation and reduces atherosclerosis in low-density lipoprotein receptor-deficient mice.
10/2007	Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance.

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Motohiro Sekiya Research Topics

Disease

14	Atherosclerosis 03/2019 - 08/2002
10	Obesity 03/2020 - 12/2003
8	Insulin Resistance 03/2020 - 12/2003
5	Type 2 Diabetes Mellitus (MODY) 01/2021 - 12/2015
4	Inflammation (Inflammations) 03/2020 - 01/2017
4	Hyperlipidemias (Hyperlipidemia) 07/2018 - 01/2016
4	Hypertriglyceridemia 01/2018 - 08/2011
3	Hyperglycemia 12/2015 - 12/2003
2	Starvation 01/2021 - 11/2007
2	Non-alcoholic Fatty Liver Disease 01/2020 - 07/2017
2	Body Weight (Weight, Body) 01/2019 - 07/2018
2	Hypercholesterolemia 11/2016 - 09/2006
2	Fatty Liver 12/2015 - 05/2004
2	Neoplasms (Cancer) 06/2005 - 07/2003
1	Diabetic Retinopathy (Retinopathy, Diabetic) 01/2022
1	Muscle Weakness 01/2022
1	Cognitive Dysfunction 01/2021
1	Hyperuricemia 01/2020
1	Albuminuria 07/2018
1	Dyslipidemias (Dyslipidemia) 07/2018
1	Diabetic Nephropathies (Diabetic Nephropathy) 07/2018
1	Hypoxia (Hypoxemia) 04/2018
1	Lipodystrophy 01/2018
1	Fibrosis (Cirrhosis) 01/2018
1	Weight Loss (Weight Reduction) 11/2017
1	Hypoglycemia (Reactive Hypoglycemia) 01/2016
1	Metabolic Diseases (Metabolic Disease) 12/2015
1	Liver Diseases (Liver Disease) 05/2015
1	Hepatomegaly 05/2015
1	Hyperlipoproteinemia Type I (Lipoprotein Lipase Deficiency, Familial) 01/2013
1	Atherosclerotic Plaque (Atheroma) 08/2011
1	Hepatocellular Carcinoma (Hepatoma) 06/2005
1	Hyperinsulinism (Hyperinsulinemia) 12/2003

Drug/Important Bio-Agent (IBA)

9	CholesterolIBA 03/2019 - 08/2002
6	Cholesterol Esters (Cholesteryl Esters)IBA 10/2014 - 08/2002
5	Glucose (Dextrose)FDA LinkGeneric 03/2020 - 12/2015
5	LipidsIBA 01/2019 - 11/2008
5	Sterol Esterase (Hormone-Sensitive Lipase)IBA 01/2011 - 08/2002
4	Transcription Factors (Transcription Factor)IBA 01/2021 - 07/2003
4	Insulin (Novolin)FDA Link 01/2020 - 09/2009
4	Triglycerides (Triacylglycerol)IBA 07/2018 - 06/2005
4	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 07/2018 - 04/2017
4	Sterol Regulatory Element Binding Protein 1IBA 01/2018 - 06/2005
4	Fatty Acids (Saturated Fatty Acids)IBA 07/2017 - 10/2007
4	EnzymesIBA 01/2016 - 06/2005
3	Fatty Acid ElongasesIBA 01/2020 - 10/2007
3	oxidized low density lipoproteinIBA 07/2018 - 09/2006
3	LDL Receptors (LDL Receptor)IBA 04/2017 - 08/2011
3	Messenger RNA (mRNA)IBA 11/2007 - 06/2005
2	fibroblast growth factor 21IBA 03/2020 - 07/2018
2	Sucrose (Saccharose)IBA 03/2020 - 01/2020
2	Proteins (Proteins, Gene)FDA Link 01/2020 - 12/2015
2	Farnesyl-Diphosphate Farnesyltransferase (Squalene Synthase)IBA 05/2015 - 09/2006
2	Lipoproteins (Lipoprotein)IBA 08/2011 - 07/2004
2	ElementsIBA 08/2011 - 05/2004
2	SterolsIBA 08/2011 - 05/2004
2	LeptinIBA 09/2009 - 12/2003
1	Biomarkers (Surrogate Marker)IBA 01/2021
1	CeramidesIBA 01/2020
1	Uric Acid (Urate)IBA 01/2020
1	Phospholipases (Phospholipase)IBA 01/2020
1	1-octacosanol (octacosanol)IBA 01/2019
1	policosanolIBA 01/2019
1	Fenofibrate (CiL)FDA LinkGeneric 07/2018
1	(R)-2-(3-((benzoxazol-2-yl-d4 (3- (4- methoxyphenoxy- d7)propyl)amino)methyl)phenoxy) butanoic acidIBA 07/2018
1	Malondialdehyde (Propanedial)IBA 07/2018
1	LDL CholesterolIBA 07/2018
1	Reactive Oxygen Species (Oxygen Radicals)IBA 04/2018
1	LigandsIBA 01/2018
1	PhosphoenolpyruvateIBA 01/2018
1	Genetic Markers (Genetic Marker)IBA 01/2018
1	Sodium-Glucose Transporter 2 InhibitorsIBA 11/2017
1	Sodium-Glucose Transport ProteinsIBA 11/2017
1	Pharmaceutical PreparationsIBA 04/2017
1	PalmitatesIBA 01/2017
1	Oleic Acid (Oleate)IBA 01/2017
1	Co-Repressor ProteinsIBA 01/2016
1	Fatty Acid-Binding ProteinsIBA 12/2015
1	AdipokinesIBA 12/2015
1	Monoclonal AntibodiesIBA 12/2015
1	Blood Glucose (Blood Sugar)IBA 12/2015
1	FarnesolIBA 05/2015
1	OxysterolsIBA 10/2014
1	Apolipoprotein C-II (ApoC2)IBA 01/2013
1	Lipoprotein Lipase (Diacylglycerol Lipase)IBA 01/2013
1	Apolipoproteins C (ApoC)IBA 01/2013
1	Monounsaturated Fatty AcidsIBA 09/2011
1	VLDL LipoproteinsIBA 08/2011
1	VLDL CholesterolIBA 08/2011
1	HDL CholesterolIBA 08/2011
1	Protein Kinase C-epsilonIBA 10/2007
1	Insulin Receptor Substrate ProteinsIBA 10/2007
1	low density lipoprotein inhibitorIBA 07/2004
1	PPAR alphaIBA 12/2003

Therapy/Procedure

1	Cardiopulmonary Resuscitation (CPR) 01/2022
1	Intravenous Injections 09/2006